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Malarone effectively prevents and treats malaria. It has the least side effects out of all malaria tablets. Take one tablet a day for guaranteed results.

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Doxycycline is a tetracycline antibiotic which protects you from malaria. This anti malaria treatment can be taken at short notice, 2 days before your trip.

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Lariam is an affordable anti malaria tablet. It is ideal for those with busy lifestyles; tablets need to be taken just once a week.

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Malaria is a potentially fatal disease that affects hundreds of travellers from the UK each year and causes almost a million deaths worldwide. It is prevalent in parts of Asia, Africa and South America (see diagram for detailed map). Spread by infected mosquitoes, travellers to risk areas should take the necessary precautions highlighted below. Furthermore, the right anti malaria tablet provides invaluable protection. The risk profile is higher for children, pregnant women and immunosuppressed individuals or those with ongoing medical conditions.

What Is Malaria?

Malaria is a highly infectious disease that is spread by mosquitoes that can be life-threatening if not diagnosed and treated in time. Symptoms will usually include bouts of fever, lethargy, severe headaches and vomiting. If it is left untreated, these symptoms can develop into seizures, organ failure and death.

What Are The Symptoms Of Malaria?

Malaria can start with flu-like symptoms. These may include one of or all of the following:

  • fever
  • hot and cold chills
  • intense sweating
  • joint pain
  • severe headaches or migraines
  • vomiting
  • diarrhoea
  • lethargy and in severe cases, seizures.

These symptoms can take a week or more (sometimes up to 3 years in the case of P.Vivax) to develop after being bitten by an infected mosquito, however, any signs of these symptoms after spending time in a malaria-endemic country should be assessed by a doctor immediately.

  • Seek immediate medical advice if you experience any of the above symptoms for up to a year after exposure, even after completing a course of antimalarial tablets.
  • If you are travelling to multiple malaria-endemic countries and spending a long time there, it would be advisable to take a suitable course of anti-malaria treatment and a malaria testing kit with you. Anti-malaria medication can be used for extended periods of time, however, any long trips to affected areas should be discussed with your GP first.

How Many Types Of Malaria Are There?

There are five different types of malaria which depend on the parasite the mosquito is carrying:

  • Plasmodium Falciparum – This is the most common type of malaria parasite and is the main cause of most malaria deaths worldwide. Location: Predominantly Africa
  • Plasmodium Vivax – This particular parasite is known to cause less severe symptoms than Plasmodium Falciparum but both are responsible for infecting the majority of humans worldwide. Worryingly, it can reside in the liver for up to 3 years, resulting in potential relapses of malaria. Location: Asia / South America
  • Plasmodium Ovale – This is an uncommon variant of malaria that is similar to Plasmodium Vivax as it can stay in your liver for a number of years without any noticeable symptoms. Location: Western Africa
  • Plasmodium Malariae – A rare variant of the malaria parasite that is often referred to as “benign malaria” due it being considerably less dangerous than P. Falciparum and P. Vivax. Symptoms are known to be fevers that recur every three days (known as Quartan Fever). Location: Africa
  • Plasmodium Knowlesi – This relatively rare variant causes malaria in macaques but has also been known to severely infect humans, in particular, inhabitants of or travellers to forested areas in Southeast Asia such as parts of Borneo. Location: Southeast Asia

Where Is Malaria Most Common?

Malaria occurs in over 100 countries and territories, yet is most prevalent in the world’s tropical and subtropical countries, in particular, the African subcontinent, Asia, Central and Southern America, the Caribbean, Oceania and the Indo-Pacific region. In these areas, transmission of malaria is accelerated by high temperature and high degree of water availability, creating suitable climatic conditions for the mosquito to grow.

Warm, tropical weather is a crucial element in the proliferation of malaria, particularly as the parasite will make use of the warm conditions to spread.

  • Africa
  • South Asia
  • Parts of Central and South America
  • The Caribbean
  • Southeast Asia
  • The Middle East
  • Oceania (Fiji, Polynesia etc)

How Does Malaria Spread?

Malaria can be spread by a single bite of an infected female Anopheles Mosquito. These infected mosquitoes carry a parasite known as Plasmodium, which is transmitted into the bloodstream of the bitten individual. If a mosquito bites a person that has already contracted malaria, it can become infected and thus further spread the disease. Malaria cannot be spread directly from person to person.

Once bitten, the Plasmodium parasite travels through the bloodstream to the liver in order to begin the infection. Once the infection has developed, the parasite will again enter the bloodstream in order to begin attacking the red blood cells. It is here, amongst the red blood cells, that plasmodium begins to multiply, releasing more parasites that continue to infect the blood.

There are, in fact, many different types of Plasmodium but only five of them cause malaria in humans.

Once the parasites are in the bloodstream, they make their way to the liver. Here they begin to duplicate until the point when they’re released back into the bloodstream in significantly higher numbers.

They can then invade the red blood cells and, once inside, continue to multiply until the cells explode. This releases more parasites into the bloodstream.

Not only does the parasite infect humans, but any mosquito that bites a human infected with the parasite can then spread the disease further.

Which Malaria Tablets Are Available Online?

Each prescription anti-malaria treatment works differently and which you use can depend on the length of your trip abroad and your budget. Some are taken daily, with a short course taken prior to your trip such as:

Malarone Tablets: Malarone effectively prevents and treats malaria while providing fewer side effects.

Doxycycline: Doxycycline is ideal for situations with short notice. It can be taken just two days before your trip.

Lariam: Lariam is a more affordable antimalarial. It is also more convenient - you only need to take one tablet a week.

Compare Treatments


Malarone (Atovaquone/Proguanil) Lariam (Mefloquine)
How Often To Take One tablet daily One tablet daily One tablet weekly
Starting Treatment 1-2 days before entering malaria area 1-2 days before entering malaria area At least one week and (preferably 2 - 3 weeks) before entering malaria area
Finishing Treatment 4 weeks after leaving malaria area 1 week after leaving malaria area 4 weeks after leaving malaria area
Common Side Effects Can cause skin sensitivity to sunlight Rare Mood changes, anxiety and dizziness

Which Malaria Tablets Should I Choose?

  • Check your destination(s) on fitfortravel.nhs.uk to determine which antimalarial if any is required.
  • When used as recommended by fitfortravel.nhs.uk, Doxycycline, Malarone or Lariam are equally effective in preventing malaria (no anti-malaria tablets is 100% effective)
  • Lariam is not suitable for patients with active depression, a recent history of depression, generalized anxiety disorder, psychosis, or schizophrenia or other major psychiatric disorders, or with a history of convulsions.
  • Doxycycline may cause your skin to become more sensitive to sunlight. It is recommended to avoid strong direct sunlight. Erythema (sunburn) due to increased sunlight photosensitivity can occur in 4-16% of users, use of a high SPF sunscreen reduces this risk.

How To Avoid Mosquito Bites

Mosquitoes can bite you at any time of the day, however most bites occur during the night, at dusk or at dawn due to the fact that the female anopheles mosquito is most active during these times.

  • Wear long-sleeved clothing to cover exposed ankles, feet and legs if you are out at dusk, dawn or at night. Avoid shorts if possible!
  • Use insect repellent containing at least 50% DEET on exposed skin and under thin clothing, particularly around the ankles.
  • Avoid exposing too much skin after dusk in malaria-endemic countries, especially if you are out and about. Cover your legs and feet when in woodland or near water and carry insect spray with you.
  • Insect repellent sprays, candles and mosquito coils can reduce the risk of bites.
  • Where possible sleep in rooms with closed or screened windows and use a mosquito net in combination with insecticide sprays
  • Ultrasound devices, Vitamin B, perfume, homeopathic products, tonic water, and citronella are not proven to protect against mosquito bites.
  • Long-lasting Insecticidal Nets provide the most effective personal protection against mosquito bites and can be vital for people most at risk of malaria (such as young children, pregnant women). These nets can last up to 3 years.

Quick Facts About Malaria

  • Only the female Anopheles mosquito spreads malaria
  • Young children, pregnant women and immune suppressed or non-immune travellers are the most vulnerable when infected
  • The highest transmission of Malaria is found in South of the Sahara in Africa, and in Papua New Guinea
  • Even in Malaria-endemic countries, transmission will not occur at high altitude, during cold seasons or in the desert.
  • Although very rare, malaria can be transmitted through blood transfusion, organ transplant and shared needles
  • In 2015, there were almost 200 million cases of malaria, with an estimated 429,000 deaths
  • In 2015, Sub-Saharan Africa experienced 90% of malaria cases and 92% of malaria-related deaths globally.
  • In 2013, around 437,000 African children died before their fifth birthday due to malaria
  • There is currently no malaria vaccine approved for human use

Compare Treatments

Doxycycline Malarone (Atovaquone/Proguanil) Lariam (Mefloquine)
How Often To Take One tablet daily One tablet daily One tablet weekly
Starting Treatment 1-2 days before entering malaria area 1-2 days before entering malaria area At least one week and (preferably 2 - 3 weeks) before entering malaria area
Finishing Treatment 4 weeks after leaving malaria area 1 week after leaving malaria area 4 weeks after leaving malaria area
Common Side effects Can cause skin sensitivity to sunlight Rare Mood changes, anxiety and dizziness

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